Pain Receptor in Brain May be Linked to Learning & Memory
Scientists have long known that the nervous system receptor known as TRPV1 can affect sensations of pain in the body. Now a group of Brown University scientists has found that these receptors - a darling of drug developers - also may play a role in learning and memory in the brain. In surprising new research, published in the journal Neuron, Julie Kauer and her team show that activation of TPRV1 receptors can trigger long-term depression, a phenomenon that creates lasting changes in the connections between neurons. These changes in the brain - and the related process of neural reorganization known as long-term potentiation - are believed to be the cellular basis for memory making. "We've known that TRPV1 receptors are in the brain, but this is some of the first evidence of what they actually do there," Kauer said. "And the functional role we uncovered is unexpected. No one has previously linked these pain receptors to a cellular mechanism underlying memory. So we may...